TNFRSF10D

Entrez Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RO-3306 3 to 4μM on day4 R04 exp165	-2.03
Cannabidiol 13μM R08 exp465	-1.96
Oligomycin-A 20μM R00 exp26	-1.96
Isoniazid 100μM R08 exp494	-1.92
Prochlorperazine 5.2μM R02 exp77	-1.87
Phenformin 20μM R03 exp143	-1.85
Golgicide-A 2μM R03 exp121	-1.84
Nicotine 3000μM R08 exp510	-1.75
Isonicotinamide 500μM R03 exp129	-1.71
TRAIL 50ng/ml R00 exp36	1.74
GSK591 2.6μM R03 exp128	1.77
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.78
Cycloheximide 0.2μM R00 exp15	2.15

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution