TNFRSF9
Gene Information
- Official Symbol: TNFRSF9
- Official Name: TNF receptor superfamily member 9
- Aliases and Previous Symbols: N/A
- Entrez ID: 3604
- UniProt: Q07011
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008].
- UniProt Summary: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7815
- Expression level (log2 read counts): 3.86
TNFRSF9 Expression in NALM6 Cells: 3.86
