TPPP3

Entrez Summary: N/A
UniProt Summary: Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis. {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:19633818}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mdivi-1 15μM R05 exp217	-2.07
Mubritinib 0.2μM R01 exp48	-1.89
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.87
Atovaquone 15μM R08 exp451	-1.82
PFI-2 4μM R05 exp239	-1.74
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.71
HMS-I1 1μM R01 exp46	1.78
MK2206 4μM R08 exp504	1.89

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution