UniProt Summary: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. {ECO:0000269|PubMed:12645956, ECO:0000269|PubMed:18650384}.
Pfam DomainsGO Terms
Pfam Domains
V-set
GO Terms
signaling receptor activity
T cell activation
lymphocyte activation
regulation of innate immune response
regulation of response to biotic stimulus
cell surface
regulation of defense response
regulation of multi-organism process
leukocyte activation
cell activation
regulation of response to external stimulus
regulation of immune response
regulation of response to stress
regulation of immune system process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)