TRIM23
Gene Information
- Official Symbol: TRIM23
- Official Name: tripartite motif containing 23
- Aliases and Previous Symbols: N/A
- Entrez ID: 373
- UniProt: P36406
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090). {ECO:0000269|PubMed:15684077, ECO:0000269|PubMed:28871090}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14580
- Expression level (log2 read counts): 3.9
TRIM23 Expression in NALM6 Cells: 3.9
