TRIM38
Gene Information
- Official Symbol: TRIM38
- Official Name: tripartite motif containing 38
- Aliases and Previous Symbols: N/A
- Entrez ID: 10475
- UniProt: O00635
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. {ECO:0000269|PubMed:23056470}.
Pfam Domains GO Terms
Pfam Domains
| SPRY |
| zf-C3HC4 |
| zf-B box |
GO Terms
| positive regulation of viral entry into host cell |
| negative regulation of defense response to virus |
| regulation of viral entry into host cell |
| positive regulation of viral genome replication |
| regulation of interferon-beta production |
| protein K48-linked ubiquitination |
| transferase activity |
| positive regulation of viral life cycle |
| interferon-gamma-mediated signaling pathway |
| regulation of defense response to virus |
| negative regulation of response to biotic stimulus |
| regulation of viral genome replication |
| positive regulation of viral process |
| negative regulation of immune effector process |
| regulation of type I interferon production |
| regulation of viral life cycle |
| positive regulation of NF-kappaB transcription factor activity |
| cellular response to interferon-gamma |
| response to interferon-gamma |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of viral process |
| negative regulation of defense response |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| positive regulation of DNA-binding transcription factor activity |
| protein polyubiquitination |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| negative regulation of response to external stimulus |
| regulation of DNA-binding transcription factor activity |
| negative regulation of immune system process |
| cellular component |
| regulation of immune effector process |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| cytokine-mediated signaling pathway |
| protein catabolic process |
| protein ubiquitination |
| regulation of cytokine production |
| regulation of defense response |
| innate immune response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| zinc ion binding |
| cellular macromolecule catabolic process |
| defense response to other organism |
| protein modification by small protein conjugation or removal |
| cellular response to cytokine stimulus |
| positive regulation of intracellular signal transduction |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| regulation of response to external stimulus |
| response to cytokine |
| proteolysis |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of response to stress |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of immune system process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17958
- Expression level (log2 read counts): 7.1
Expression Distribution
TRIM38 Expression in NALM6 Cells: 7.1
