TUBB3
Gene Information
- Official Symbol: TUBB3
- Official Name: tubulin beta 3 class III
- Aliases and Previous Symbols: N/A
- Entrez ID: 10381
- UniProt: Q13509
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010].
- UniProt Summary: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. {ECO:0000269|PubMed:20074521}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5035
- Expression level (log2 read counts): 2.74
TUBB3 Expression in NALM6 Cells: 2.74
