UQCRB
Gene Information
- Official Symbol: UQCRB
- Official Name: ubiquinol-cytochrome c reductase binding protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 7381
- UniProt: P14927
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011].
- UniProt Summary: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2158
- Expression level (log2 read counts): 5.74
UQCRB Expression in NALM6 Cells: 5.74
