ZDHHC16
Gene Information
- Official Symbol: ZDHHC16
- Official Name: zinc finger DHHC-type palmitoyltransferase 16
- Aliases and Previous Symbols: N/A
- Entrez ID: 84287
- UniProt: Q969W1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). {ECO:0000250|UniProtKB:B8A4F0, ECO:0000250|UniProtKB:Q9ESG8, ECO:0000269|PubMed:28826475}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5271
- Expression level (log2 read counts): 4.98
ZDHHC16 Expression in NALM6 Cells: 4.98
