ZFYVE19
Gene Information
- Official Symbol: ZFYVE19
- Official Name: zinc finger FYVE-type containing 19
- Aliases and Previous Symbols: N/A
- Entrez ID: 84936
- UniProt: Q96K21
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. {ECO:0000269|PubMed:24814515}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4380
- Expression level (log2 read counts): 5.08
ZFYVE19 Expression in NALM6 Cells: 5.08
