ZNRF1
Gene Information
- Official Symbol: ZNRF1
- Official Name: zinc and ring finger 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 84937
- UniProt: Q8ND25
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). {ECO:0000305|PubMed:14561866}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14295
- Expression level (log2 read counts): 4.73
ZNRF1 Expression in NALM6 Cells: 4.73
