ACAA2
Gene Information
- Official Symbol: ACAA2
- Official Name: acetyl-CoA acyltransferase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10449
- UniProt: P42765
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Abolishes BNIP3-mediated apoptosis and mitochondrial damage. {ECO:0000269|PubMed:18371312}.
Pfam Domains GO Terms
Pfam Domains
| Thiolase C |
| Thiolase N |
GO Terms
| negative regulation of mitochondrial membrane permeability involved in apoptotic process |
| acetyl-CoA C-acetyltransferase activity |
| acetyl-CoA C-acyltransferase activity |
| acetyl-CoA hydrolase activity |
| negative regulation of mitochondrial membrane permeability |
| negative regulation of membrane permeability |
| negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| myristoyl-CoA hydrolase activity |
| palmitoyl-CoA hydrolase activity |
| acyl-CoA hydrolase activity |
| regulation of mitochondrial membrane permeability involved in apoptotic process |
| cholesterol biosynthetic process |
| secondary alcohol biosynthetic process |
| regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| sterol biosynthetic process |
| negative regulation of mitochondrion organization |
| fatty acid beta-oxidation |
| apoptotic mitochondrial changes |
| regulation of mitochondrial membrane permeability |
| fatty acid oxidation |
| lipid oxidation |
| regulation of membrane permeability |
| fatty acid catabolic process |
| alcohol biosynthetic process |
| cholesterol metabolic process |
| monocarboxylic acid catabolic process |
| steroid biosynthetic process |
| mitochondrial membrane organization |
| secondary alcohol metabolic process |
| sterol metabolic process |
| regulation of mitochondrion organization |
| organic hydroxy compound biosynthetic process |
| cellular response to hypoxia |
| cellular lipid catabolic process |
| cellular response to decreased oxygen levels |
| lipid modification |
| cellular response to oxygen levels |
| mitochondrial transport |
| negative regulation of apoptotic signaling pathway |
| steroid metabolic process |
| organic acid catabolic process |
| carboxylic acid catabolic process |
| lipid catabolic process |
| alcohol metabolic process |
| fatty acid metabolic process |
| response to hypoxia |
| response to decreased oxygen levels |
| mitochondrial matrix |
| negative regulation of organelle organization |
| response to oxygen levels |
| regulation of apoptotic signaling pathway |
| small molecule catabolic process |
| mitochondrion organization |
| organic hydroxy compound metabolic process |
| negative regulation of transport |
| monocarboxylic acid metabolic process |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| negative regulation of cellular component organization |
| membrane organization |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| apoptotic process |
| cellular lipid metabolic process |
| oxidation-reduction process |
| negative regulation of cell death |
| oxoacid metabolic process |
| organic acid metabolic process |
| programmed cell death |
| cell death |
| response to abiotic stimulus |
| lipid metabolic process |
| mitochondrion |
| negative regulation of signal transduction |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| RNA binding |
| regulation of apoptotic process |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| regulation of cell death |
| cellular response to stress |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Thalidomide 20μM R07 exp406 | 1.81 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17326
- Expression level (log2 read counts): 5.48
Expression Distribution
ACAA2 Expression in NALM6 Cells: 5.48
