ACAD8
Gene Information
- Official Symbol: ACAD8
- Official Name: acyl-CoA dehydrogenase family member 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 27034
- UniProt: Q9UKU7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009].
- UniProt Summary: Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex. {ECO:0000269|PubMed:12359132}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5081
- Expression level (log2 read counts): 5.48
ACAD8 Expression in NALM6 Cells: 5.48
