ACAT1
Gene Information
- Official Symbol: ACAT1
- Official Name: acetyl-CoA acetyltransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 38
- UniProt: P24752
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009].
- UniProt Summary: Plays a major role in ketone body metabolism.
Pfam Domains GO Terms
Pfam Domains
| Thiolase C |
| Thiolase N |
GO Terms
| proximal convoluted tubule development |
| propionyl-CoA biosynthetic process |
| C-acetyltransferase activity |
| metanephric proximal convoluted tubule development |
| propionyl-CoA metabolic process |
| isoleucine metabolic process |
| metanephric proximal tubule development |
| acetyl-CoA catabolic process |
| isoleucine catabolic process |
| ketone body catabolic process |
| acetyl-CoA C-acetyltransferase activity |
| steroid esterification |
| sterol esterification |
| cholesterol esterification |
| proximal tubule development |
| acetyl-CoA C-acyltransferase activity |
| ribonucleoside bisphosphate catabolic process |
| purine nucleoside bisphosphate catabolic process |
| nucleoside bisphosphate catabolic process |
| ketone body biosynthetic process |
| coenzyme A biosynthetic process |
| coenzyme binding |
| cellular ketone body metabolic process |
| fatty acid derivative catabolic process |
| ketone body metabolic process |
| acetyl-CoA biosynthetic process |
| metanephric nephron tubule development |
| coenzyme A metabolic process |
| coenzyme catabolic process |
| metanephric nephron epithelium development |
| metanephric tubule development |
| metanephric epithelium development |
| branched-chain amino acid catabolic process |
| branched-chain amino acid metabolic process |
| acetyl-CoA metabolic process |
| fatty-acyl-CoA biosynthetic process |
| purine ribonucleotide catabolic process |
| ribonucleotide catabolic process |
| adipose tissue development |
| fatty-acyl-CoA metabolic process |
| purine nucleotide catabolic process |
| thioester biosynthetic process |
| acyl-CoA biosynthetic process |
| purine-containing compound catabolic process |
| sulfur compound catabolic process |
| fatty acid beta-oxidation |
| ribonucleoside bisphosphate biosynthetic process |
| nucleoside bisphosphate biosynthetic process |
| purine nucleoside bisphosphate biosynthetic process |
| cofactor catabolic process |
| nucleotide catabolic process |
| nucleoside phosphate catabolic process |
| nephron tubule development |
| fatty acid oxidation |
| lipid oxidation |
| renal tubule development |
| metanephros development |
| fatty acid derivative biosynthetic process |
| fatty acid catabolic process |
| thioester metabolic process |
| nephron epithelium development |
| acyl-CoA metabolic process |
| alpha-amino acid catabolic process |
| nucleobase-containing small molecule biosynthetic process |
| monocarboxylic acid catabolic process |
| nephron development |
| cellular amino acid catabolic process |
| liver development |
| organophosphate catabolic process |
| kidney epithelium development |
| hepaticobiliary system development |
| purine nucleoside bisphosphate metabolic process |
| ribonucleoside bisphosphate metabolic process |
| nucleoside bisphosphate metabolic process |
| coenzyme biosynthetic process |
| drug catabolic process |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| fatty acid derivative metabolic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| sulfur compound biosynthetic process |
| carbohydrate derivative catabolic process |
| response to starvation |
| cellular lipid catabolic process |
| lipid modification |
| alpha-amino acid metabolic process |
| cofactor biosynthetic process |
| connective tissue development |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| steroid metabolic process |
| organic acid catabolic process |
| carboxylic acid catabolic process |
| kidney development |
| renal system development |
| lipid catabolic process |
| cellular amino acid metabolic process |
| purine ribonucleotide metabolic process |
| urogenital system development |
| fatty acid metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| protein homooligomerization |
| enzyme binding |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| mitochondrial matrix |
| nucleobase-containing compound catabolic process |
| gland development |
| generation of precursor metabolites and energy |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| small molecule catabolic process |
| cofactor metabolic process |
| aromatic compound catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic cyclic compound catabolic process |
| response to nutrient levels |
| drug metabolic process |
| protein complex oligomerization |
| amide biosynthetic process |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| brain development |
| head development |
| cellular amide metabolic process |
| tube development |
| protein homodimerization activity |
| organophosphate metabolic process |
| response to hormone |
| carboxylic acid metabolic process |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| oxidation-reduction process |
| central nervous system development |
| oxoacid metabolic process |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| organonitrogen compound catabolic process |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| lipid metabolic process |
| mitochondrion |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| response to endogenous stimulus |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| tissue development |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rotenone 0.07μM R08 exp431 | -2.74 |
| QNZ 0.01μM R08 exp439 | -1.95 |
| NMS-873 0.07μM R07 exp380 | -1.88 |
| QNZ 0.01μM R05 exp241 | -1.87 |
| Chloramphenicol 20μM R00 exp13 | -1.86 |
| Cryptotanshinone 12μM R05 exp227 | -1.82 |
| Phenformin 20μM R05 exp212 | -1.73 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MADCAM1 | 0.406 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18367
- Expression level (log2 read counts): 5.92
Expression Distribution
ACAT1 Expression in NALM6 Cells: 5.92
