ADAMTS14
Gene Information
- Official Symbol: ADAMTS14
- Official Name: ADAM metallopeptidase with thrombospondin type 1 motif 14
- Aliases and Previous Symbols: N/A
- Entrez ID: 140766
- UniProt: Q8WXS8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016].
- UniProt Summary: Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6342
- Expression level (log2 read counts): -3.51
ADAMTS14 Expression in NALM6 Cells: -3.51
