ADCY1
Gene Information
- Official Symbol: ADCY1
- Official Name: adenylate cyclase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 107
- UniProt: Q08828
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
- UniProt Summary: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). {ECO:0000250|UniProtKB:O88444, ECO:0000250|UniProtKB:P19754}.
Pfam Domains GO Terms
Pfam Domains
| Guanylate cyc |
GO Terms
| calcium- and calmodulin-responsive adenylate cyclase activity |
| adenylate cyclase activity |
| cAMP biosynthetic process |
| cellular response to forskolin |
| response to forskolin |
| response to platelet aggregation inhibitor |
| activation of protein kinase A activity |
| positive regulation of CREB transcription factor activity |
| positive regulation of long-term synaptic potentiation |
| response to lithium ion |
| cAMP metabolic process |
| cyclic purine nucleotide metabolic process |
| cyclic nucleotide biosynthetic process |
| cellular response to glucagon stimulus |
| long-term memory |
| hippocampal mossy fiber to CA3 synapse |
| renal water homeostasis |
| response to glucagon |
| activation of adenylate cyclase activity |
| neuroinflammatory response |
| cyclic nucleotide metabolic process |
| regulation of long-term synaptic potentiation |
| integral component of postsynaptic density membrane |
| multicellular organismal water homeostasis |
| water homeostasis |
| regulation of synaptic vesicle exocytosis |
| Schaffer collateral - CA1 synapse |
| cellular response to calcium ion |
| cellular response to alcohol |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| cellular response to ketone |
| regulation of neurotransmitter secretion |
| renal system process |
| regulation of synaptic vesicle cycle |
| regulation of circadian rhythm |
| memory |
| cellular response to antibiotic |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| circadian rhythm |
| regulation of neurotransmitter transport |
| cAMP-mediated signaling |
| purine ribonucleotide biosynthetic process |
| positive regulation of synaptic transmission |
| response to calcium ion |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| regulation of regulated secretory pathway |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| cyclic-nucleotide-mediated signaling |
| regulation of synaptic plasticity |
| cellular response to metal ion |
| response to ketone |
| calmodulin binding |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| cellular response to inorganic substance |
| regulation of exocytosis |
| membrane raft |
| response to alcohol |
| nucleotide biosynthetic process |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| nucleoside phosphate biosynthetic process |
| learning or memory |
| positive regulation of DNA-binding transcription factor activity |
| cellular response to peptide hormone stimulus |
| rhythmic process |
| cognition |
| response to antibiotic |
| purine ribonucleotide metabolic process |
| multicellular organismal homeostasis |
| ribonucleotide metabolic process |
| cellular response to peptide |
| activation of protein kinase activity |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| second-messenger-mediated signaling |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| purine-containing compound metabolic process |
| response to metal ion |
| axonogenesis |
| response to peptide hormone |
| cellular response to drug |
| axon development |
| regulation of DNA-binding transcription factor activity |
| cell morphogenesis involved in neuron differentiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| response to peptide |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of body fluid levels |
| inflammatory response |
| cell part morphogenesis |
| cellular response to lipid |
| response to inorganic substance |
| positive regulation of protein kinase activity |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| cellular response to organic cyclic compound |
| regulation of vesicle-mediated transport |
| cell morphogenesis involved in differentiation |
| behavior |
| positive regulation of kinase activity |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| carbohydrate derivative biosynthetic process |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| neuron projection development |
| cell morphogenesis |
| brain development |
| regulation of secretion by cell |
| head development |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| response to lipid |
| regulation of kinase activity |
| organophosphate metabolic process |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of transferase activity |
| central nervous system development |
| response to organonitrogen compound |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| response to drug |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| organic cyclic compound biosynthetic process |
| G protein-coupled receptor signaling pathway |
| defense response |
| nervous system process |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| ATP binding |
| generation of neurons |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| cell development |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nocodazole 0.1μM R03 exp94 | 1.74 |
| Nocodazole 0.2μM R02 exp64 | 2.17 |
| Sulforaphane 9μM R08 exp526 no dilution day6 | 2.21 |
| Rotenone 2μM R00 exp33 | 2.36 |
| Nocodazole 0.2μM R00 exp24 | 2.54 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.758 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5435
- Expression level (log2 read counts): 4.74
Expression Distribution
ADCY1 Expression in NALM6 Cells: 4.74
