ADCY7

Gene Information

Official Symbol: ADCY7
Official Name: adenylate cyclase 7
Aliases and Previous Symbols: N/A
Entrez ID: 113
UniProt: P51828
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Pfam Domains GO Terms

Pfam Domains

DUF1053

Guanylate cyc

GO Terms

adenylate cyclase activity

cAMP biosynthetic process

cellular response to lithium ion

cellular response to ethanol

negative regulation of cytokine production involved in inflammatory response

activation of protein kinase A activity

response to lithium ion

cAMP metabolic process

cyclic purine nucleotide metabolic process

cyclic nucleotide biosynthetic process

cellular response to glucagon stimulus

renal water homeostasis

response to glucagon

activation of adenylate cyclase activity

regulation of cytokine production involved in inflammatory response

cyclic nucleotide metabolic process

maternal process involved in female pregnancy

multicellular organismal water homeostasis

water homeostasis

cellular response to alcohol

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

renal system process

cellular response to antibiotic

response to ethanol

adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of inflammatory response

cAMP-mediated signaling

purine ribonucleotide biosynthetic process

purine nucleotide biosynthetic process

regulation of adaptive immune response

ribonucleotide biosynthetic process

ribose phosphate biosynthetic process

purine-containing compound biosynthetic process

cyclic-nucleotide-mediated signaling

female pregnancy

cellular response to metal ion

negative regulation of defense response

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

multi-multicellular organism process

cellular response to toxic substance

cellular response to inorganic substance

response to alcohol

nucleotide biosynthetic process

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

nucleoside phosphate biosynthetic process

cellular response to peptide hormone stimulus

negative regulation of cytokine production

response to antibiotic

purine ribonucleotide metabolic process

multicellular organismal homeostasis

ribonucleotide metabolic process

cellular response to peptide

activation of protein kinase activity

purine nucleotide metabolic process

ribose phosphate metabolic process

second-messenger-mediated signaling

regulation of inflammatory response

negative regulation of response to external stimulus

purine-containing compound metabolic process

response to metal ion

response to peptide hormone

cellular response to drug

nucleotide metabolic process

nucleoside phosphate metabolic process

response to peptide

regulation of body fluid levels

response to toxic substance

positive regulation of protein kinase activity

response to inorganic substance

organophosphate biosynthetic process

nucleobase-containing small molecule metabolic process

positive regulation of kinase activity

cellular response to organonitrogen compound

cellular response to hormone stimulus

carbohydrate derivative biosynthetic process

positive regulation of transferase activity

cellular response to nitrogen compound

regulation of cytokine production

regulation of defense response

regulation of protein kinase activity

multicellular organismal reproductive process

multicellular organism reproduction

regulation of kinase activity

organophosphate metabolic process

response to hormone

regulation of transferase activity

multi-organism reproductive process

response to organonitrogen compound

positive regulation of protein phosphorylation

response to drug

carbohydrate derivative metabolic process

cellular response to oxygen-containing compound

positive regulation of phosphorylation

response to nitrogen compound

regulation of response to external stimulus

nucleobase-containing compound biosynthetic process

chemical homeostasis

positive regulation of phosphorus metabolic process

positive regulation of phosphate metabolic process

regulation of immune response

heterocycle biosynthetic process

aromatic compound biosynthetic process

negative regulation of multicellular organismal process

cellular response to endogenous stimulus

positive regulation of protein modification process

organic cyclic compound biosynthetic process

G protein-coupled receptor signaling pathway

integral component of plasma membrane

organonitrogen compound biosynthetic process

reproductive process

reproduction

positive regulation of catalytic activity

regulation of protein phosphorylation

response to endogenous stimulus

regulation of response to stress

ATP binding

response to oxygen-containing compound

regulation of phosphorylation

positive regulation of cellular protein metabolic process

negative regulation of response to stimulus

cellular nitrogen compound biosynthetic process

homeostatic process

regulation of immune system process

intracellular signal transduction

positive regulation of protein metabolic process

small molecule metabolic process

positive regulation of molecular function

regulation of phosphate metabolic process

regulation of phosphorus metabolic process

regulation of protein modification process

system process

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
Aphidicolin 0.4μM R08 exp440	-1.81

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3690
Expression level (log2 read counts): 4.56

Expression Distribution