ANKFY1
Gene Information
- Official Symbol: ANKFY1
- Official Name: ankyrin repeat and FYVE domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 51479
- UniProt: Q9P2R3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1- dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051, ECO:0000269|PubMed:24102721}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6419
- Expression level (log2 read counts): 6.86
ANKFY1 Expression in NALM6 Cells: 6.86
