AP1S1
Gene Information
- Official Symbol: AP1S1
- Official Name: adaptor related protein complex 1 subunit sigma 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1174
- UniProt: P61966
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008].
- UniProt Summary: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000269|PubMed:9733768}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5135
- Expression level (log2 read counts): 4.65
AP1S1 Expression in NALM6 Cells: 4.65
