Pfam Domains GO Terms
| P21-Arc |
| growth cone leading edge |
| actin polymerization-dependent cell motility |
| Arp2/3 protein complex |
| Arp2/3 complex-mediated actin nucleation |
| actin nucleation |
| filamentous actin |
| cellular response to nerve growth factor stimulus |
| response to nerve growth factor |
| site of double-strand break |
| ephrin receptor signaling pathway |
| positive regulation of actin filament polymerization |
| structural constituent of cytoskeleton |
| positive regulation of protein polymerization |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| regulation of actin filament polymerization |
| lamellipodium |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| actin filament binding |
| actin cytoskeleton |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| actin filament organization |
| Fc receptor signaling pathway |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| phagocytosis |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| focal adhesion |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| immune response-regulating cell surface receptor signaling pathway |
| actin cytoskeleton organization |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| response to growth factor |
| regulation of cytoskeleton organization |
| immune response-activating signal transduction |
| actin filament-based process |
| immune response-regulating signaling pathway |
| positive regulation of organelle organization |
| activation of immune response |
| enzyme linked receptor protein signaling pathway |
| membrane organization |
| positive regulation of immune response |
| regulation of cellular component biogenesis |
| cell motility |
| localization of cell |
| immune effector process |
| cytoskeleton organization |
| regulation of immune response |
| positive regulation of immune system process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| regulation of organelle organization |
| locomotion |
| response to endogenous stimulus |
| movement of cell or subcellular component |
| regulation of immune system process |
| vesicle-mediated transport |
| membrane |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| PU-H71 1μM R08 exp515 | 1.74 |
| DABN 2μM R00 exp16 | 1.81 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 1/28 |
| bone | 2/26 |
| breast | 1/33 |
| central nervous system | 3/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 2/21 |
| liver | 4/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 2/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 2/9 |
| thyroid | 2/2 |
| upper aerodigestive | 3/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Expression Distribution