UniProt Summary: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth. {ECO:0000269|PubMed:15451426}.
Pfam DomainsGO Terms
Pfam Domains
Sds3
GO Terms
Sin3-type complex
histone deacetylase activity
histone deacetylation
protein deacetylation
protein deacylation
macromolecule deacylation
histone deacetylase binding
histone modification
covalent chromatin modification
regulation of growth
chromatin organization
negative regulation of transcription by RNA polymerase II
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)