BST1
Gene Information
- Official Symbol: BST1
- Official Name: bone marrow stromal cell antigen 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 683
- UniProt: Q10588
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth. {ECO:0000269|PubMed:11866528}.
Pfam Domains GO Terms
Pfam Domains
| Rib hydrolayse |
GO Terms
| ADP-ribosyl cyclase activity |
| cyclic ADP-ribose hydrolase |
| NAD+ nucleotidase, cyclic ADP-ribose generating |
| NAD+ nucleosidase activity |
| NAD(P)+ nucleosidase activity |
| phosphorus-oxygen lyase activity |
| uropod |
| regulation of integrin-mediated signaling pathway |
| regulation of neutrophil chemotaxis |
| regulation of cellular extravasation |
| regulation of superoxide metabolic process |
| regulation of neutrophil migration |
| positive regulation of B cell proliferation |
| regulation of granulocyte chemotaxis |
| NAD metabolic process |
| transferase activity |
| regulation of B cell proliferation |
| extrinsic component of membrane |
| specific granule membrane |
| regulation of calcium-mediated signaling |
| anchored component of membrane |
| regulation of leukocyte chemotaxis |
| regulation of cell-matrix adhesion |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte proliferation |
| positive regulation of B cell activation |
| regulation of reactive oxygen species metabolic process |
| regulation of leukocyte migration |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of cell-substrate adhesion |
| regulation of chemotaxis |
| regulation of leukocyte proliferation |
| regulation of peptidyl-tyrosine phosphorylation |
| regulation of inflammatory response |
| regulation of actin cytoskeleton organization |
| humoral immune response |
| positive regulation of lymphocyte activation |
| regulation of actin filament-based process |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of cytoskeleton organization |
| myeloid leukocyte activation |
| regulation of leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| regulation of cell adhesion |
| regulated exocytosis |
| regulation of defense response |
| leukocyte mediated immunity |
| exocytosis |
| regulation of cell migration |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| leukocyte activation |
| regulation of locomotion |
| regulation of cellular component movement |
| secretion by cell |
| export from cell |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| secretion |
| positive regulation of immune system process |
| regulation of organelle organization |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| regulation of immune system process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16902
- Expression level (log2 read counts): 1.81
Expression Distribution
BST1 Expression in NALM6 Cells: 1.81
