BTG1
Gene Information
- Official Symbol: BTG1
- Official Name: BTG anti-proliferation factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 694
- UniProt: P62324
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Anti-proliferative protein. {ECO:0000269|PubMed:1373383}.
Pfam Domains GO Terms
Pfam Domains
| BTG |
GO Terms
| positive regulation of fibroblast apoptotic process |
| positive regulation of endothelial cell differentiation |
| regulation of fibroblast apoptotic process |
| positive regulation of myoblast differentiation |
| regulation of endothelial cell differentiation |
| regulation of myoblast differentiation |
| positive regulation of epithelial cell differentiation |
| transcription coregulator activity |
| kinase binding |
| protein alkylation |
| protein methylation |
| regulation of epithelial cell differentiation |
| positive regulation of angiogenesis |
| negative regulation of cell growth |
| positive regulation of vasculature development |
| negative regulation of growth |
| macromolecule methylation |
| regulation of angiogenesis |
| negative regulation of mitotic cell cycle |
| methylation |
| regulation of vasculature development |
| enzyme binding |
| response to oxidative stress |
| response to peptide hormone |
| regulation of cell growth |
| response to peptide |
| spermatogenesis |
| male gamete generation |
| negative regulation of cell cycle |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of growth |
| negative regulation of cell population proliferation |
| gamete generation |
| positive regulation of cell death |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| response to hormone |
| cell migration |
| positive regulation of cell differentiation |
| multi-organism reproductive process |
| response to organonitrogen compound |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| regulation of cell cycle |
| locomotion |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CNOT8 | 0.608 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17766
- Expression level (log2 read counts): 6.2
Expression Distribution
BTG1 Expression in NALM6 Cells: 6.2
