CACNB2
Gene Information
- Official Symbol: CACNB2
- Official Name: calcium voltage-gated channel auxiliary subunit beta 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 783
- UniProt: Q08289
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Guanylate kin |
| VGCC beta4Aa N |
GO Terms
| positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| voltage-gated calcium channel activity involved in AV node cell action potential |
| membrane depolarization during atrial cardiac muscle cell action potential |
| voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels |
| positive regulation of presynaptic cytosolic calcium concentration |
| induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration |
| voltage-gated calcium channel activity involved in cardiac muscle cell action potential |
| positive regulation of high voltage-gated calcium channel activity |
| membrane depolarization during AV node cell action potential |
| photoreceptor ribbon synapse |
| AV node cell to bundle of His cell signaling |
| AV node cell action potential |
| positive regulation of synaptic vesicle exocytosis |
| high voltage-gated calcium channel activity |
| AV node cell to bundle of His cell communication |
| regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| positive regulation of voltage-gated calcium channel activity |
| L-type voltage-gated calcium channel complex |
| atrial cardiac muscle cell action potential |
| presynaptic modulation of chemical synaptic transmission |
| atrial cardiac muscle cell to AV node cell signaling |
| atrial cardiac muscle cell to AV node cell communication |
| regulation of high voltage-gated calcium channel activity |
| regulation of presynaptic cytosolic calcium ion concentration |
| membrane depolarization during cardiac muscle cell action potential |
| positive regulation of neurotransmitter secretion |
| voltage-gated calcium channel complex |
| cell-cell signaling involved in cardiac conduction |
| membrane depolarization during action potential |
| neuron cellular homeostasis |
| regulation of voltage-gated calcium channel activity |
| regulation of heart rate by cardiac conduction |
| positive regulation of neurotransmitter transport |
| cardiac muscle cell action potential involved in contraction |
| positive regulation of calcium ion transmembrane transporter activity |
| voltage-gated calcium channel activity |
| cardiac muscle cell contraction |
| neuromuscular junction development |
| calcium ion import |
| cell communication involved in cardiac conduction |
| cardiac muscle cell action potential |
| membrane depolarization |
| positive regulation of regulated secretory pathway |
| calcium channel activity |
| positive regulation of cation channel activity |
| positive regulation of calcium ion transmembrane transport |
| cardiac muscle contraction |
| regulation of synaptic vesicle exocytosis |
| heart contraction |
| regulation of calcium ion transmembrane transporter activity |
| positive regulation of exocytosis |
| actin-mediated cell contraction |
| cardiac conduction |
| presynapse |
| action potential |
| regulation of heart rate |
| heart process |
| positive regulation of ion transmembrane transporter activity |
| regulation of neurotransmitter secretion |
| striated muscle contraction |
| actin filament-based movement |
| positive regulation of transporter activity |
| regulation of synaptic vesicle cycle |
| positive regulation of calcium ion transport |
| multicellular organismal signaling |
| positive regulation of cation transmembrane transport |
| regulation of neurotransmitter transport |
| regulation of calcium ion transmembrane transport |
| positive regulation of synaptic transmission |
| positive regulation of ion transmembrane transport |
| regulation of regulated secretory pathway |
| regulation of cation channel activity |
| protein localization to plasma membrane |
| calcium ion transmembrane transport |
| positive regulation of transmembrane transport |
| actin filament binding |
| visual perception |
| regulation of exocytosis |
| sensory perception of light stimulus |
| protein localization to cell periphery |
| regulation of heart contraction |
| regulation of calcium ion transport |
| calcium ion transport |
| muscle contraction |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| synapse organization |
| positive regulation of ion transport |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| divalent metal ion transport |
| muscle system process |
| divalent inorganic cation transport |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| anatomical structure homeostasis |
| regulation of neurotransmitter levels |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| positive regulation of secretion by cell |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| regulation of membrane potential |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| divalent inorganic cation homeostasis |
| regulation of vesicle-mediated transport |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| actin filament-based process |
| regulation of system process |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| cation transport |
| cellular homeostasis |
| regulation of cellular localization |
| ion transmembrane transport |
| sensory perception |
| positive regulation of transport |
| chemical homeostasis |
| cell-cell signaling |
| transmembrane transport |
| ion transport |
| nervous system process |
| integral component of plasma membrane |
| movement of cell or subcellular component |
| cellular protein localization |
| cellular macromolecule localization |
| homeostatic process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pifithrin-alpha 20μM R07 exp390 | 1.8 |
| Docosahexaenoic-acid 50μM R07 exp356 | 2.07 |
| Taxol 0.002μM R01 exp54 | 2.22 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11874
- Expression level (log2 read counts): 4.71
Expression Distribution
CACNB2 Expression in NALM6 Cells: 4.71
