CD34
Gene Information
- Official Symbol: CD34
- Official Name: CD34 molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 947
- UniProt: P28906
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
Pfam Domains GO Terms
Pfam Domains
| CD34 antigen |
GO Terms
| glomerular endothelium fenestra |
| negative regulation of cellular response to heat |
| extracellular exosome assembly |
| mesangial cell-matrix adhesion |
| positive regulation of glial cell-derived neurotrophic factor secretion |
| metanephric glomerular mesangial cell differentiation |
| metanephric mesangial cell differentiation |
| regulation of glial cell-derived neurotrophic factor secretion |
| positive regulation of granulocyte colony-stimulating factor production |
| glomerular endothelium development |
| metanephric glomerular mesangium development |
| positive regulation of macrophage colony-stimulating factor production |
| negative regulation of interleukin-2 secretion |
| sulfate binding |
| regulation of granulocyte colony-stimulating factor production |
| regulation of macrophage colony-stimulating factor production |
| vascular wound healing |
| metanephric glomerulus vasculature development |
| extracellular exosome biogenesis |
| glomerular mesangial cell differentiation |
| paracrine signaling |
| negative regulation of cellular response to hypoxia |
| regulation of interleukin-2 secretion |
| mesangial cell differentiation |
| transdifferentiation |
| glomerular mesangium development |
| pericyte cell differentiation |
| extracellular vesicle biogenesis |
| positive regulation of vasculogenesis |
| metanephric glomerulus development |
| glomerular filtration |
| positive regulation of odontogenesis |
| renal filtration |
| regulation of cellular response to hypoxia |
| hematopoietic stem cell proliferation |
| negative regulation of nitric oxide biosynthetic process |
| negative regulation of nitric oxide metabolic process |
| regulation of vasculogenesis |
| angiogenesis involved in wound healing |
| cell differentiation involved in metanephros development |
| glomerulus vasculature development |
| positive regulation of transforming growth factor beta production |
| renal system vasculature development |
| glomerular epithelium development |
| kidney vasculature development |
| negative regulation of interleukin-2 production |
| endothelial cell proliferation |
| regulation of odontogenesis |
| negative regulation of reactive oxygen species biosynthetic process |
| epithelial cell differentiation involved in kidney development |
| metanephric nephron development |
| basal plasma membrane |
| regulation of transforming growth factor beta production |
| positive regulation of interleukin-10 production |
| cell differentiation involved in kidney development |
| negative regulation of blood coagulation |
| negative regulation of hemostasis |
| glomerulus development |
| negative regulation of coagulation |
| regulation of interleukin-10 production |
| stem cell proliferation |
| regulation of interleukin-2 production |
| negative regulation of reactive oxygen species metabolic process |
| regulation of nitric oxide biosynthetic process |
| intercellular bridge |
| negative regulation of tumor necrosis factor production |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of cytokine secretion |
| negative regulation of wound healing |
| regulation of blood coagulation |
| regulation of cellular response to heat |
| regulation of hemostasis |
| positive regulation of animal organ morphogenesis |
| regulation of coagulation |
| metanephros development |
| regulation of reactive oxygen species biosynthetic process |
| negative regulation of response to wounding |
| epithelial cell proliferation |
| endothelium development |
| nephron epithelium development |
| renal system process |
| nephron development |
| cell-matrix adhesion |
| kidney epithelium development |
| negative regulation of protein secretion |
| regulation of wound healing |
| positive regulation of cytokine secretion |
| negative regulation of peptide secretion |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of angiogenesis |
| regulation of response to wounding |
| carbohydrate binding |
| regulation of reactive oxygen species metabolic process |
| negative regulation of protein transport |
| regulation of blood pressure |
| positive regulation of vasculature development |
| cell-substrate adhesion |
| negative regulation of establishment of protein localization |
| tissue homeostasis |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| negative regulation of neuron death |
| connective tissue development |
| negative regulation of secretion |
| lysosome |
| regulation of animal organ morphogenesis |
| kidney development |
| positive regulation of protein secretion |
| negative regulation of cytokine production |
| renal system development |
| regulation of angiogenesis |
| positive regulation of peptide secretion |
| vesicle organization |
| regulation of neuron death |
| angiogenesis |
| apical plasma membrane |
| urogenital system development |
| regulation of vasculature development |
| multicellular organismal homeostasis |
| transcription factor binding |
| anatomical structure homeostasis |
| regulation of neurotransmitter levels |
| negative regulation of response to external stimulus |
| leukocyte migration |
| extracellular structure organization |
| blood circulation |
| external side of plasma membrane |
| circulatory system process |
| positive regulation of secretion by cell |
| blood vessel morphogenesis |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| wound healing |
| negative regulation of transport |
| blood vessel development |
| regulation of peptide secretion |
| regulation of body fluid levels |
| cell-cell adhesion |
| vasculature development |
| cardiovascular system development |
| cell population proliferation |
| hemopoiesis |
| response to wounding |
| hematopoietic or lymphoid organ development |
| immune system development |
| tube morphogenesis |
| epithelial cell differentiation |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| organelle assembly |
| regulation of secretion |
| tube development |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| cell adhesion |
| biological adhesion |
| cell migration |
| positive regulation of cell differentiation |
| positive regulation of transport |
| negative regulation of cell death |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| regulation of response to external stimulus |
| epithelium development |
| cell-cell signaling |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| locomotion |
| positive regulation of developmental process |
| integral component of plasma membrane |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| regulation of transport |
| system process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| LLY-284 2.6μM R06 exp291 | -2.09 |
| Palbociclib 1μM R07 exp382 | -1.83 |
| Deguelin 0.15μM R05 exp209 | -1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14528
- Expression level (log2 read counts): 2.12
Expression Distribution
CD34 Expression in NALM6 Cells: 2.12
