CD36
Gene Information
- Official Symbol: CD36
- Official Name: CD36 molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 948
- UniProt: P16671
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| CD36 |
GO Terms
| oxidised low-density lipoprotein particle receptor activity |
| oxidised low-density lipoprotein particle clearance |
| lipoteichoic acid receptor activity |
| regulation of blood microparticle formation |
| positive regulation of blood microparticle formation |
| response to linoleic acid |
| lipoprotein particle mediated signaling |
| low-density lipoprotein particle mediated signaling |
| toll-like receptor TLR6:TLR2 signaling pathway |
| cellular response to diacyl bacterial lipopeptide |
| thrombospondin receptor activity |
| response to diacyl bacterial lipopeptide |
| triglyceride transport |
| acylglycerol transport |
| response to stilbenoid |
| sterol import |
| Toll-like receptor binding |
| cellular response to bacterial lipoprotein |
| cholesterol import |
| cellular response to bacterial lipopeptide |
| response to bacterial lipopeptide |
| response to bacterial lipoprotein |
| positive regulation of NLRP3 inflammasome complex assembly |
| lipoprotein particle binding |
| positive regulation of cholesterol storage |
| amyloid-beta clearance by cellular catabolic process |
| cellular response to hydroperoxide |
| regulation of protein heterodimerization activity |
| amyloid fibril formation |
| positive regulation of macrophage cytokine production |
| interleukin-1 beta secretion |
| cellular response to lipoteichoic acid |
| lipid import into cell |
| cellular response to oxidised low-density lipoprotein particle stimulus |
| high-density lipoprotein particle binding |
| regulation of removal of superoxide radicals |
| long-chain fatty acid import into cell |
| response to lipoteichoic acid |
| intestinal cholesterol absorption |
| interleukin-1 secretion |
| lipoprotein localization |
| negative regulation of protein import into nucleus |
| intestinal lipid absorption |
| negative regulation of protein import |
| low-density lipoprotein particle receptor activity |
| lipoprotein transport |
| positive regulation of membrane invagination |
| positive regulation of phagocytosis, engulfment |
| regulation of macrophage cytokine production |
| lipid digestion |
| regulation of cholesterol storage |
| regulation of NLRP3 inflammasome complex assembly |
| regulation of phagocytosis, engulfment |
| interleukin-1 beta production |
| regulation of membrane invagination |
| production of molecular mediator involved in inflammatory response |
| positive regulation of macrophage derived foam cell differentiation |
| low-density lipoprotein particle binding |
| interleukin-1 production |
| platelet alpha granule membrane |
| cellular response to low-density lipoprotein particle stimulus |
| positive regulation of myeloid leukocyte cytokine production involved in immune response |
| response to hydroperoxide |
| negative regulation of nucleocytoplasmic transport |
| nitric oxide mediated signal transduction |
| positive regulation of lipid storage |
| transforming growth factor beta binding |
| amyloid-beta clearance |
| low-density lipoprotein particle clearance |
| regulation of lipopolysaccharide-mediated signaling pathway |
| cGMP-mediated signaling |
| positive regulation of hemostasis |
| positive regulation of blood coagulation |
| response to lipoprotein particle |
| positive regulation of coagulation |
| negative regulation of protein localization to nucleus |
| lipid storage |
| regulation of macrophage derived foam cell differentiation |
| cellular response to lipoprotein particle stimulus |
| MyD88-dependent toll-like receptor signaling pathway |
| intestinal absorption |
| regulation of superoxide metabolic process |
| regulation of response to reactive oxygen species |
| energy homeostasis |
| positive regulation of interleukin-12 production |
| cellular response to amyloid-beta |
| apoptotic cell clearance |
| positive regulation of nitric oxide biosynthetic process |
| positive regulation of nitric oxide metabolic process |
| plasma lipoprotein particle clearance |
| negative regulation of intracellular protein transport |
| regulation of lipid storage |
| cytokine secretion |
| response to amyloid-beta |
| regulation of action potential |
| scavenger receptor activity |
| positive regulation of reactive oxygen species biosynthetic process |
| positive regulation of cell-matrix adhesion |
| brush border membrane |
| cholesterol transport |
| positive regulation of cytokine production involved in immune response |
| positive regulation of wound healing |
| regulation of interleukin-12 production |
| regulation of protein import into nucleus |
| regulation of nitric oxide biosynthetic process |
| long-chain fatty acid transport |
| regulation of protein import |
| negative regulation of intracellular transport |
| phagocytic vesicle |
| receptor internalization |
| positive regulation of response to wounding |
| sterol transport |
| sensory perception of taste |
| endocytic vesicle membrane |
| positive regulation of phagocytosis |
| regulation of toll-like receptor signaling pathway |
| regulation of plasma lipoprotein particle levels |
| fatty acid transport |
| digestive system process |
| regulation of cellular response to oxidative stress |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| regulation of blood coagulation |
| regulation of hemostasis |
| cell |
| positive regulation of lipid localization |
| amyloid-beta binding |
| regulation of coagulation |
| regulation of cytokine production involved in immune response |
| response to fatty acid |
| regulation of response to oxidative stress |
| positive regulation of tumor necrosis factor production |
| regulation of reactive oxygen species biosynthetic process |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| specific granule membrane |
| defense response to Gram-positive bacterium |
| positive regulation of interleukin-6 production |
| regulation of phagocytosis |
| positive regulation of reactive oxygen species metabolic process |
| positive regulation of production of molecular mediator of immune response |
| antigen processing and presentation of peptide antigen via MHC class I |
| positive regulation of cold-induced thermogenesis |
| toll-like receptor signaling pathway |
| positive regulation of endocytosis |
| receptor metabolic process |
| regulation of nucleocytoplasmic transport |
| phagocytosis, recognition |
| negative regulation of cellular protein localization |
| digestion |
| regulation of cell-matrix adhesion |
| regulation of protein localization to nucleus |
| positive regulation of cell-substrate adhesion |
| pattern recognition receptor signaling pathway |
| phagocytosis, engulfment |
| platelet degranulation |
| monocarboxylic acid transport |
| organic hydroxy compound transport |
| plasma membrane invagination |
| regulation of lipid localization |
| regulation of wound healing |
| regulation of interleukin-6 production |
| regulation of production of molecular mediator of immune response |
| regulation of cold-induced thermogenesis |
| membrane invagination |
| regulation of tumor necrosis factor production |
| cytokine production |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of tumor necrosis factor superfamily cytokine production |
| lipid binding |
| protein secretion |
| establishment of protein localization to extracellular region |
| maintenance of location |
| protein localization to extracellular region |
| regulation of response to wounding |
| cyclic-nucleotide-mediated signaling |
| peptide secretion |
| antigen processing and presentation of exogenous peptide antigen |
| regulation of reactive oxygen species metabolic process |
| negative regulation of protein transport |
| antigen processing and presentation of exogenous antigen |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| cellular response to lipopolysaccharide |
| negative regulation of establishment of protein localization |
| antigen processing and presentation of peptide antigen |
| positive regulation of peptidyl-tyrosine phosphorylation |
| cellular response to molecule of bacterial origin |
| receptor complex |
| regulation of endocytosis |
| regulation of cell-substrate adhesion |
| positive regulation of ERK1 and ERK2 cascade |
| cellular response to biotic stimulus |
| antigen processing and presentation |
| positive regulation of immune effector process |
| regulation of protein binding |
| membrane raft |
| regulation of intracellular protein transport |
| innate immune response-activating signal transduction |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| receptor-mediated endocytosis |
| cell recognition |
| cellular response to oxidative stress |
| positive regulation of protein complex assembly |
| regulation of peptidyl-tyrosine phosphorylation |
| activation of innate immune response |
| positive regulation of DNA-binding transcription factor activity |
| protein-containing complex binding |
| positive regulation of cytosolic calcium ion concentration |
| carboxylic acid transport |
| organic acid transport |
| regulation of ERK1 and ERK2 cascade |
| blood coagulation |
| coagulation |
| hemostasis |
| lipid transport |
| response to lipopolysaccharide |
| apical plasma membrane |
| lipid localization |
| fatty acid metabolic process |
| multicellular organismal homeostasis |
| response to molecule of bacterial origin |
| cellular response to peptide |
| regulation of cytosolic calcium ion concentration |
| phagocytosis |
| defense response to bacterium |
| second-messenger-mediated signaling |
| positive regulation of innate immune response |
| response to acid chemical |
| regulation of intracellular transport |
| regulation of neurotransmitter levels |
| positive regulation of response to biotic stimulus |
| regulation of binding |
| response to oxidative stress |
| external side of plasma membrane |
| regulation of lipid metabolic process |
| positive regulation of cell adhesion |
| regulation of DNA-binding transcription factor activity |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| positive regulation of cytokine production |
| regulation of protein complex assembly |
| regulation of innate immune response |
| supramolecular fiber organization |
| organic anion transport |
| regulation of immune effector process |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| positive regulation of defense response |
| wound healing |
| negative regulation of transport |
| neutrophil degranulation |
| divalent inorganic cation homeostasis |
| neutrophil activation involved in immune response |
| regulation of body fluid levels |
| neutrophil mediated immunity |
| inflammatory response |
| neutrophil activation |
| granulocyte activation |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| positive regulation of cellular component biogenesis |
| cellular response to lipid |
| myeloid cell activation involved in immune response |
| regulation of response to biotic stimulus |
| monocarboxylic acid metabolic process |
| sensory perception of chemical stimulus |
| regulation of cellular protein localization |
| positive regulation of MAPK cascade |
| regulation of vesicle-mediated transport |
| endocytosis |
| cellular metal ion homeostasis |
| immune response-activating signal transduction |
| response to wounding |
| anion transport |
| myeloid leukocyte activation |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| cell surface |
| leukocyte activation involved in immune response |
| metal ion homeostasis |
| cell activation involved in immune response |
| activation of immune response |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| import into cell |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| regulated exocytosis |
| cation homeostasis |
| regulation of protein transport |
| inorganic ion homeostasis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of MAPK cascade |
| regulation of defense response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| ion homeostasis |
| exocytosis |
| membrane organization |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| cellular homeostasis |
| carboxylic acid metabolic process |
| regulation of cellular localization |
| response to organic cyclic compound |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| defense response to other organism |
| cellular lipid metabolic process |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| sensory perception |
| Golgi apparatus |
| positive regulation of transport |
| response to organonitrogen compound |
| oxoacid metabolic process |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| regulation of protein localization |
| export from cell |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| positive regulation of developmental process |
| ion transport |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| integral component of plasma membrane |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| negative regulation of cellular biosynthetic process |
| peptide transport |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| amide transport |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| nitrogen compound transport |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.432 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18563
- Expression level (log2 read counts): 0.72
Expression Distribution
CD36 Expression in NALM6 Cells: 0.72
