CDK5RAP2
Gene Information
- Official Symbol: CDK5RAP2
- Official Name: CDK5 regulatory subunit associated protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 55755
- UniProt: Q96SN8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]. COMPLETENESS: complete on the 3' end.
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Microtub assoc |
GO Terms
| negative regulation of centriole replication |
| gamma-tubulin ring complex |
| negative regulation of centrosome duplication |
| negative regulation of centrosome cycle |
| regulation of mitotic cell cycle spindle assembly checkpoint |
| regulation of spindle checkpoint |
| regulation of mitotic spindle checkpoint |
| centriole replication |
| microtubule plus-end |
| pericentriolar material |
| regulation of centriole replication |
| centriole assembly |
| gamma-tubulin binding |
| mitotic spindle pole |
| establishment of mitotic spindle orientation |
| positive regulation of microtubule polymerization |
| centrosome duplication |
| regulation of cell cycle checkpoint |
| establishment of mitotic spindle localization |
| positive regulation of microtubule polymerization or depolymerization |
| establishment of spindle orientation |
| negative regulation of organelle assembly |
| establishment of spindle localization |
| regulation of centrosome duplication |
| spindle localization |
| regulation of mitotic metaphase/anaphase transition |
| regulation of microtubule polymerization |
| regulation of metaphase/anaphase transition of cell cycle |
| tubulin binding |
| regulation of mitotic sister chromatid separation |
| regulation of centrosome cycle |
| regulation of chromosome separation |
| regulation of mitotic sister chromatid segregation |
| regulation of sister chromatid segregation |
| regulation of microtubule polymerization or depolymerization |
| centrosome cycle |
| microtubule bundle formation |
| microtubule organizing center organization |
| ciliary basal body-plasma membrane docking |
| regulation of chromosome segregation |
| microtubule cytoskeleton organization involved in mitosis |
| establishment of cell polarity |
| spindle pole |
| positive regulation of protein polymerization |
| G2/M transition of mitotic cell cycle |
| cell cycle G2/M phase transition |
| negative regulation of cytoskeleton organization |
| regulation of mitotic nuclear division |
| organelle localization by membrane tethering |
| membrane docking |
| regulation of microtubule cytoskeleton organization |
| regulation of nuclear division |
| regulation of G2/M transition of mitotic cell cycle |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| calmodulin binding |
| regulation of cell cycle G2/M phase transition |
| transcription regulatory region DNA binding |
| positive regulation of cytoskeleton organization |
| regulation of organelle assembly |
| regulation of microtubule-based process |
| regulation of protein polymerization |
| negative regulation of neuron differentiation |
| microtubule binding |
| positive regulation of protein complex assembly |
| mitotic cell cycle phase transition |
| chromosome segregation |
| cell cycle phase transition |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| microtubule |
| negative regulation of cell cycle process |
| negative regulation of cell development |
| cilium assembly |
| regulation of chromosome organization |
| regulation of supramolecular fiber organization |
| establishment of organelle localization |
| cytoskeleton |
| cilium organization |
| negative regulation of organelle organization |
| regulation of mitotic cell cycle phase transition |
| plasma membrane bounded cell projection assembly |
| regulation of cell cycle phase transition |
| regulation of protein complex assembly |
| cell projection assembly |
| protein kinase binding |
| microtubule cytoskeleton organization |
| centrosome |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| cell junction |
| negative regulation of cell cycle |
| organelle localization |
| mitotic cell cycle process |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| regulation of neuron differentiation |
| microtubule-based process |
| mitotic cell cycle |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| negative regulation of cell differentiation |
| brain development |
| regulation of cell cycle process |
| organelle assembly |
| head development |
| regulation of neurogenesis |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| central nervous system development |
| Golgi apparatus |
| cell cycle process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| cell cycle |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nicotinamide 2000μM R01 exp50 | -2.34 |
| Cytochalasin-B 5μM R07 exp349 | -2.06 |
| CHIR-124 0.04μM R06 exp272 | 1.92 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2906
- Expression level (log2 read counts): 7.45
Expression Distribution
CDK5RAP2 Expression in NALM6 Cells: 7.45
