CELA1
Gene Information
- Official Symbol: CELA1
- Official Name: chymotrypsin like elastase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1990
- UniProt: Q9UNI1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts upon elastin.
Pfam Domains GO Terms
Pfam Domains
| Trypsin |
GO Terms
| elastin catabolic process |
| pancreas morphogenesis |
| elastin metabolic process |
| exocrine pancreas development |
| glycoprotein catabolic process |
| exocrine system development |
| pancreas development |
| multicellular organism growth |
| post-embryonic development |
| tissue remodeling |
| digestive system development |
| positive regulation of angiogenesis |
| serine-type endopeptidase activity |
| positive regulation of vasculature development |
| carbohydrate derivative catabolic process |
| regulation of angiogenesis |
| regulation of vasculature development |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| glycoprotein metabolic process |
| developmental growth |
| growth |
| gland development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| inflammatory response |
| protein catabolic process |
| negative regulation of transcription by RNA polymerase II |
| cellular macromolecule catabolic process |
| animal organ morphogenesis |
| carbohydrate derivative metabolic process |
| macromolecule catabolic process |
| regulation of anatomical structure morphogenesis |
| organonitrogen compound catabolic process |
| cell-cell signaling |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| proteolysis |
| negative regulation of RNA metabolic process |
| defense response |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| extracellular space |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nocodazole 0.2μM R00 exp24 | -1.77 |
| Brefeldin A 0.02μM R00 exp8 | -1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18358
- Expression level (log2 read counts): -6.6
Expression Distribution
CELA1 Expression in NALM6 Cells: -6.6
