CGNL1
Gene Information
- Official Symbol: CGNL1
- Official Name: cingulin like 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 84952
- UniProt: Q0VF96
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011].
- UniProt Summary: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. {ECO:0000269|PubMed:22891260}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2997
- Expression level (log2 read counts): 1.25
CGNL1 Expression in NALM6 Cells: 1.25
