CHAMP1
Gene Information
- Official Symbol: CHAMP1
- Official Name: chromosome alignment maintaining phosphoprotein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 283489
- UniProt: Q96JM3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with an autosomal dominant form of intellectual disability. [provided by RefSeq, Jul 2017].
- UniProt Summary: Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1753
- Expression level (log2 read counts): 6.14
CHAMP1 Expression in NALM6 Cells: 6.14
