CLINT1
Gene Information
- Official Symbol: CLINT1
- Official Name: clathrin interactor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9685
- UniProt: Q14677
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].
- UniProt Summary: Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13479
- Expression level (log2 read counts): 6.87
CLINT1 Expression in NALM6 Cells: 6.87
