CNNM2
Gene Information
- Official Symbol: CNNM2
- Official Name: cyclin and CBS domain divalent metal cation transport mediator 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 54805
- UniProt: Q9H8M5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
- UniProt Summary: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). {ECO:0000250|UniProtKB:Q3TWN3}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16095
- Expression level (log2 read counts): 5.34
CNNM2 Expression in NALM6 Cells: 5.34
