UniProt Summary: The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit.
Pfam DomainsGO Terms
Pfam Domains
LRR 4
GO Terms
enzyme regulator activity
regulation of complement activation
regulation of humoral immune response
blood microparticle
protein stabilization
extracellular matrix
regulation of protein stability
regulation of immune effector process
regulation of immune response
extracellular space
regulation of immune system process
extracellular region
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)