UniProt Summary: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
Pfam DomainsGO Terms
Pfam Domains
Peptidase M20
Peptidase M28
GO Terms
metallodipeptidase activity
thyroid hormone generation
thyroid hormone metabolic process
carboxypeptidase activity
peptide catabolic process
tissue regeneration
phenol-containing compound metabolic process
regeneration
cellular modified amino acid metabolic process
hormone metabolic process
lysosome
developmental growth
growth
organic hydroxy compound metabolic process
wound healing
peptide metabolic process
regulation of hormone levels
response to wounding
intracellular membrane-bounded organelle
cellular amide metabolic process
protein homodimerization activity
Golgi apparatus
endoplasmic reticulum
organonitrogen compound catabolic process
proteolysis
extracellular space
tissue development
organic substance catabolic process
cellular catabolic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)