UniProt Summary: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. {ECO:0000269|PubMed:11766880, ECO:0000269|PubMed:12417617, ECO:0000269|PubMed:9099699}.
Pfam DomainsGO Terms
Pfam Domains
Fz
Peptidase M14
GO Terms
metallocarboxypeptidase activity
protein processing
protein maturation
cell-cell signaling by wnt
Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
peptide metabolic process
cellular amide metabolic process
zinc ion binding
cell-cell signaling
proteolysis
extracellular space
gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)