CROCC

Entrez Summary: N/A
UniProt Summary: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). {ECO:0000250|UniProtKB:Q8CJ40, ECO:0000269|PubMed:16203858, ECO:0000269|PubMed:27623382}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ONC212 0.15μM R08 exp513	-2.07
DABN racemic mixture R03 exp93	-1.86
5-Fluorouracil 20μM R00 exp2	-1.81
BI-6727 0.04μM R03 exp98	-1.72
Deguelin 0.15μM R05 exp209	-1.71
PF-06409577 20μM R07 exp389	1.72
Genistein 15μM R07 exp360	1.74
S-trityl-L-cysteine 0.5μM R05 exp243	1.76
CCT251545 20μM R07 exp326	1.81
FK-506 5μM R07 exp358	1.84
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.85
BRD2 inhibitor II 20μM R07 exp341	2.03
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.03
NMS-873 0.07μM R07 exp380	2.05
Lenalidomide 20μM R07 exp375	2.49

Gene	Correlation
POLE	0.417

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution