UniProt Summary: Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.
Pfam DomainsGO Terms
Pfam Domains
LIM
GO Terms
actinin binding
structural constituent of muscle
sarcomere organization
myofibril assembly
cellular component assembly involved in morphogenesis
actomyosin structure organization
Z disc
striated muscle cell development
muscle cell development
striated muscle cell differentiation
muscle cell differentiation
muscle tissue development
focal adhesion
supramolecular fiber organization
muscle structure development
actin cytoskeleton organization
actin filament-based process
organelle assembly
molecular function
cellular component morphogenesis
anatomical structure formation involved in morphogenesis
cytoskeleton organization
cell development
tissue development
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)