Entrez Summary: This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Arm
GO Terms
zonula adherens
entry of bacterium into host cell
presynaptic active zone cytoplasmic component
postsynaptic density, intracellular component
catenin complex
hippocampal mossy fiber to CA3 synapse
regulation of postsynaptic membrane neurotransmitter receptor levels
Schaffer collateral - CA1 synapse
adherens junction organization
entry into host cell
entry into host
cell-cell junction assembly
cell-cell adherens junction
growth cone
cell-cell junction organization
dendritic spine
interaction with host
midbody
cell junction assembly
cell-cell junction
negative regulation of canonical Wnt signaling pathway
lamellipodium
negative regulation of Wnt signaling pathway
cell junction organization
regulation of canonical Wnt signaling pathway
cadherin binding
signaling receptor binding
glutamatergic synapse
Wnt signaling pathway
cell-cell signaling by wnt
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
protein kinase binding
cell-cell adhesion
brain development
head development
symbiotic process
interspecies interaction between organisms
cell adhesion
biological adhesion
central nervous system development
cell-cell signaling
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)