CTSE
Gene Information
- Official Symbol: CTSE
- Official Name: cathepsin E
- Aliases and Previous Symbols: N/A
- Entrez ID: 1510
- UniProt: P14091
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015].
- UniProt Summary: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. {ECO:0000269|PubMed:8765029}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8094
- Expression level (log2 read counts): -0.69
CTSE Expression in NALM6 Cells: -0.69
