CTSL
Gene Information
- Official Symbol: CTSL
- Official Name: cathepsin L
- Aliases and Previous Symbols: N/A
- Entrez ID: 1514
- UniProt: P07711
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Important for the overall degradation of proteins in lysosomes.
Pfam Domains GO Terms
Pfam Domains
| Inhibitor I29 |
| Peptidase C1 |
GO Terms
| serpin family protein binding |
| macrophage apoptotic process |
| myeloid cell apoptotic process |
| endolysosome lumen |
| inflammatory cell apoptotic process |
| proteoglycan binding |
| cellular response to thyroid hormone stimulus |
| leukocyte apoptotic process |
| response to thyroid hormone |
| fibronectin binding |
| cysteine-type peptidase activity |
| multivesicular body |
| regulation of keratinocyte differentiation |
| collagen catabolic process |
| regulation of epidermal cell differentiation |
| collagen binding |
| collagen metabolic process |
| extracellular matrix disassembly |
| regulation of epidermis development |
| cysteine-type endopeptidase activity |
| lysosomal lumen |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| toll-like receptor signaling pathway |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| pattern recognition receptor signaling pathway |
| histone binding |
| regulation of epithelial cell differentiation |
| antigen processing and presentation of exogenous peptide antigen |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| antigen processing and presentation |
| innate immune response-activating signal transduction |
| lysosome |
| activation of innate immune response |
| extracellular matrix organization |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| collagen-containing extracellular matrix |
| extracellular structure organization |
| cellular component disassembly |
| regulation of innate immune response |
| positive regulation of defense response |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| immune response-activating signal transduction |
| proteolysis involved in cellular protein catabolic process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| adaptive immune response |
| cellular protein catabolic process |
| activation of immune response |
| protein catabolic process |
| regulation of defense response |
| regulation of multi-organism process |
| positive regulation of immune response |
| cellular macromolecule catabolic process |
| response to hormone |
| apoptotic process |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| cell death |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| cellular response to endogenous stimulus |
| proteolysis |
| response to endogenous stimulus |
| regulation of response to stress |
| extracellular space |
| regulation of immune system process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dorsomorphin 5μM R07 exp357 | -1.93 |
| BS-181 20μM R08 exp461 | -1.85 |
| LB-100 2μM R05 exp210 | 1.74 |
| AICAR 240μM R03 exp116 | 1.76 |
| THZ1 0.06μM R08 exp531 | 1.98 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.42 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15229
- Expression level (log2 read counts): -0.71
Expression Distribution
CTSL Expression in NALM6 Cells: -0.71
