DCD
Gene Information
- Official Symbol: DCD
- Official Name: dermcidin
- Aliases and Previous Symbols: N/A
- Entrez ID: 117159
- UniProt: P81605
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443). {ECO:0000269|PubMed:17448443}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16732
- Expression level (log2 read counts): -0.51
DCD Expression in NALM6 Cells: -0.51
