DMXL2
Gene Information
- Official Symbol: DMXL2
- Official Name: Dmx like 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 23312
- UniProt: Q8TDJ6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
- UniProt Summary: May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9553
- Expression level (log2 read counts): 6.48
DMXL2 Expression in NALM6 Cells: 6.48
