DNAJC6
Gene Information
- Official Symbol: DNAJC6
- Official Name: DnaJ heat shock protein family (Hsp40) member C6
- Aliases and Previous Symbols: N/A
- Entrez ID: 9829
- UniProt: O75061
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008].
- UniProt Summary: Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity). {ECO:0000250|UniProtKB:Q80TZ3}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6302
- Expression level (log2 read counts): 3.86
DNAJC6 Expression in NALM6 Cells: 3.86
