EDN2
Gene Information
- Official Symbol: EDN2
- Official Name: endothelin 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1907
- UniProt: P20800
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Endothelins are endothelium-derived vasoconstrictor peptides.
Pfam Domains GO Terms
Pfam Domains
| Endothelin |
GO Terms
| hormonal regulation of the force of heart contraction |
| positive regulation of the force of heart contraction by chemical signal |
| endothelin B receptor binding |
| positive regulation of prostaglandin-endoperoxide synthase activity |
| regulation of prostaglandin-endoperoxide synthase activity |
| vein smooth muscle contraction |
| regulation of the force of heart contraction by chemical signal |
| regulation of systemic arterial blood pressure by endothelin |
| artery smooth muscle contraction |
| tonic smooth muscle contraction |
| macrophage chemotaxis |
| vascular smooth muscle contraction |
| phasic smooth muscle contraction |
| prostanoid biosynthetic process |
| macrophage migration |
| prostaglandin biosynthetic process |
| inositol phosphate-mediated signaling |
| positive regulation of heart rate |
| regulation of the force of heart contraction |
| temperature homeostasis |
| positive regulation of smooth muscle contraction |
| vasoconstriction |
| energy homeostasis |
| prostanoid metabolic process |
| prostaglandin metabolic process |
| regulation of systemic arterial blood pressure by hormone |
| positive regulation of heart contraction |
| negative regulation of blood vessel diameter |
| lung alveolus development |
| unsaturated fatty acid biosynthetic process |
| positive regulation of muscle contraction |
| icosanoid biosynthetic process |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| endocrine process |
| macrophage activation |
| smooth muscle contraction |
| positive regulation of oxidoreductase activity |
| regulation of vasoconstriction |
| regulation of smooth muscle contraction |
| positive regulation of blood circulation |
| cell |
| neutrophil chemotaxis |
| positive regulation of leukocyte chemotaxis |
| granulocyte chemotaxis |
| fatty acid derivative biosynthetic process |
| neutrophil migration |
| regulation of systemic arterial blood pressure |
| regulation of oxidoreductase activity |
| regulation of heart rate |
| hormone activity |
| granulocyte migration |
| unsaturated fatty acid metabolic process |
| icosanoid metabolic process |
| regulation of leukocyte chemotaxis |
| fatty acid biosynthetic process |
| myeloid leukocyte migration |
| positive regulation of leukocyte migration |
| positive regulation of chemotaxis |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| leukocyte chemotaxis |
| calcium-mediated signaling |
| regulation of muscle contraction |
| fatty acid derivative metabolic process |
| vascular process in circulatory system |
| lung development |
| respiratory tube development |
| regulation of blood pressure |
| monocarboxylic acid biosynthetic process |
| respiratory system development |
| regulation of leukocyte migration |
| cell chemotaxis |
| regulation of chemotaxis |
| regulation of muscle system process |
| regulation of heart contraction |
| muscle contraction |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| muscle system process |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| fatty acid metabolic process |
| multicellular organismal homeostasis |
| regulation of cytosolic calcium ion concentration |
| second-messenger-mediated signaling |
| leukocyte migration |
| blood circulation |
| circulatory system process |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| divalent inorganic cation homeostasis |
| positive regulation of cell migration |
| regulation of anatomical structure size |
| positive regulation of cell motility |
| monocarboxylic acid metabolic process |
| positive regulation of cellular component movement |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| lipid biosynthetic process |
| myeloid leukocyte activation |
| regulation of system process |
| small molecule biosynthetic process |
| positive regulation of response to external stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cytokine-mediated signaling pathway |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| tube development |
| regulation of cell migration |
| cellular homeostasis |
| carboxylic acid metabolic process |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| leukocyte activation |
| cellular lipid metabolic process |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| organic acid metabolic process |
| cell activation |
| localization of cell |
| cell motility |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| positive regulation of immune system process |
| lipid metabolic process |
| locomotion |
| G protein-coupled receptor signaling pathway |
| positive regulation of catalytic activity |
| movement of cell or subcellular component |
| extracellular space |
| regulation of cell population proliferation |
| homeostatic process |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| positive regulation of molecular function |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 2-Methoxyestradiol 0.2μM R01 exp40 | 1.89 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4987
- Expression level (log2 read counts): -7.68
Expression Distribution
EDN2 Expression in NALM6 Cells: -7.68
