ENTPD7
Gene Information
- Official Symbol: ENTPD7
- Official Name: ectonucleoside triphosphate diphosphohydrolase 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 57089
- UniProt: Q9NQZ7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017].
- UniProt Summary: Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8326
- Expression level (log2 read counts): -1.2
ENTPD7 Expression in NALM6 Cells: -1.2
