EPB41L5
Gene Information
- Official Symbol: EPB41L5
- Official Name: erythrocyte membrane protein band 4.1 like 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 57669
- UniProt: Q9HCM4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}.
Pfam Domains GO Terms
Pfam Domains
| FERM M |
| FERM N |
| FERM C |
| FA |
GO Terms
| unidimensional cell growth |
| axial mesoderm morphogenesis |
| substrate-dependent cell migration, cell attachment to substrate |
| apical constriction |
| mesoderm migration involved in gastrulation |
| mesodermal cell migration |
| neural plate morphogenesis |
| axial mesoderm development |
| embryonic foregut morphogenesis |
| foregut morphogenesis |
| neural plate development |
| somite rostral/caudal axis specification |
| left/right axis specification |
| cell migration involved in gastrulation |
| paraxial mesoderm development |
| ectoderm development |
| left/right pattern formation |
| positive regulation of focal adhesion assembly |
| substrate-dependent cell migration |
| positive regulation of adherens junction organization |
| positive regulation of cell junction assembly |
| epithelial cell morphogenesis |
| embryonic axis specification |
| digestive tract morphogenesis |
| anterior/posterior axis specification |
| positive regulation of cell-matrix adhesion |
| regulation of cell-substrate junction assembly |
| regulation of focal adhesion assembly |
| embryonic pattern specification |
| somitogenesis |
| mesoderm formation |
| regulation of adherens junction organization |
| mesoderm morphogenesis |
| epithelial to mesenchymal transition |
| endoderm development |
| cytoskeletal protein binding |
| somite development |
| axis specification |
| regulation of cell junction assembly |
| actin-mediated cell contraction |
| cell growth |
| positive regulation of protein binding |
| tissue migration |
| ruffle membrane |
| segmentation |
| negative regulation of protein binding |
| actin filament-based movement |
| formation of primary germ layer |
| developmental growth involved in morphogenesis |
| actomyosin structure organization |
| regulation of cell-matrix adhesion |
| positive regulation of cell-substrate adhesion |
| mesoderm development |
| digestive tract development |
| positive regulation of epithelial cell migration |
| digestive system development |
| morphogenesis of embryonic epithelium |
| cellular response to transforming growth factor beta stimulus |
| mesenchymal cell differentiation |
| gastrulation |
| response to transforming growth factor beta |
| negative regulation of binding |
| ameboidal-type cell migration |
| negative regulation of cell-cell adhesion |
| positive regulation of binding |
| cell-substrate adhesion |
| epithelial cell development |
| regulation of cell-substrate adhesion |
| anterior/posterior pattern specification |
| regulation of protein binding |
| regulation of epithelial cell migration |
| mesenchyme development |
| protein domain specific binding |
| negative regulation of cell adhesion |
| regionalization |
| cytoskeleton |
| regulation of binding |
| in utero embryonic development |
| developmental growth |
| growth |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| focal adhesion |
| morphogenesis of an epithelium |
| pattern specification process |
| actin cytoskeleton organization |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| posttranscriptional regulation of gene expression |
| response to growth factor |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| actin filament-based process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| epithelial cell differentiation |
| regulation of cell adhesion |
| cell morphogenesis |
| regulation of establishment of protein localization |
| cellular component morphogenesis |
| tube development |
| regulation of cell migration |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| cell adhesion |
| biological adhesion |
| regulation of cellular component biogenesis |
| cell migration |
| embryo development |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of protein localization |
| localization of cell |
| cell motility |
| cytoskeleton organization |
| epithelium development |
| negative regulation of molecular function |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| locomotion |
| response to endogenous stimulus |
| movement of cell or subcellular component |
| cell development |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| NFN1 0.4μM R03 exp99 | 1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13938
- Expression level (log2 read counts): 4.73
Expression Distribution
EPB41L5 Expression in NALM6 Cells: 4.73
