UniProt Summary: Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions. {ECO:0000269|PubMed:20616313}.
Pfam DomainsGO Terms
Pfam Domains
IGFBP
GO Terms
positive regulation of hepatocyte growth factor receptor signaling pathway
hepatocyte growth factor receptor binding
regulation of hepatocyte growth factor receptor signaling pathway
insulin-like growth factor binding
sprouting angiogenesis
integrin binding
angiogenesis
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
tube morphogenesis
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
positive regulation of cell population proliferation
regulation of cell population proliferation
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
extracellular region
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)