Pfam Domains GO Terms
| Homeobox |
| regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification |
| cell fate specification involved in pattern specification |
| ventral spinal cord interneuron specification |
| cell fate commitment involved in pattern specification |
| ventral spinal cord interneuron fate commitment |
| ventral spinal cord interneuron differentiation |
| regulation of transcription involved in cell fate commitment |
| spinal cord dorsal/ventral patterning |
| spinal cord patterning |
| neuron fate specification |
| ventral spinal cord development |
| cell differentiation in spinal cord |
| neuron fate commitment |
| dorsal/ventral pattern formation |
| cell fate specification |
| spinal cord development |
| central nervous system neuron differentiation |
| cell fate commitment |
| regionalization |
| sequence-specific DNA binding |
| pattern specification process |
| embryo development ending in birth or egg hatching |
| DNA-binding transcription factor activity |
| embryo development |
| central nervous system development |
| neuron differentiation |
| positive regulation of transcription by RNA polymerase II |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| BI-6727 0.04μM R03 exp98 | 1.9 |
| HMS-I1 10μM R06 exp256 | 2.11 |
| Vinblastine 0.015μM R05 exp208 | 2.18 |
| Nocodazole 0.2μM R02 exp64 | 2.39 |
| SB743921 0.001μM R05 exp244 | 2.74 |
| Rotenone 2μM R00 exp33 | 2.86 |
| Nocodazole 0.2μM R00 exp24 | 3.53 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution