EZH1
Gene Information
- Official Symbol: EZH1
- Official Name: enhancer of zeste 1 polycomb repressive complex 2 subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 2145
- UniProt: Q92800
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| EZH2 WD-Binding |
| SET |
GO Terms
| establishment of chromatin silencing |
| nucleosomal histone binding |
| chromatin silencing at telomere |
| histone H3-K27 methylation |
| ESC/E(Z) complex |
| histone-lysine N-methyltransferase activity |
| chromosome, telomeric region |
| chromatin organization involved in negative regulation of transcription |
| chromatin silencing |
| chromatin organization involved in regulation of transcription |
| histone lysine methylation |
| negative regulation of gene expression, epigenetic |
| hippocampus development |
| peptidyl-lysine methylation |
| histone methylation |
| limbic system development |
| protein alkylation |
| protein methylation |
| gene silencing |
| chromatin remodeling |
| pallium development |
| regulation of gene expression, epigenetic |
| transcription corepressor activity |
| macromolecule methylation |
| telencephalon development |
| methylation |
| peptidyl-lysine modification |
| histone modification |
| covalent chromatin modification |
| forebrain development |
| chromatin binding |
| chromatin organization |
| brain development |
| head development |
| negative regulation of transcription by RNA polymerase II |
| peptidyl-amino acid modification |
| central nervous system development |
| chromosome organization |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| IU1-47 25μM R04 exp182 | -1.79 |
| 2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 | 1.73 |
| Ibrutinib 10μM R08 exp442 | 1.86 |
| Prochlorperazine 5.2μM R02 exp77 | 1.97 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12586
- Expression level (log2 read counts): 5.79
Expression Distribution
EZH1 Expression in NALM6 Cells: 5.79
