FATE1
Gene Information
- Official Symbol: FATE1
- Official Name: fetal and adult testis expressed 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 89885
- UniProt: Q969F0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010].
- UniProt Summary: Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER- mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). {ECO:0000269|PubMed:27402544, ECO:0000305|PubMed:26567849}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18711
- Expression level (log2 read counts): -7.68
FATE1 Expression in NALM6 Cells: -7.68
